Fluorouracil 5% USP Cream is a prescription topical medication used to treat precancerous and certain types of cancerous skin lesions, including actinic keratosis and superficial basal cell carcinoma. It belongs to a class of drugs known as antimetabolites and works by interfering with the growth of abnormal skin cells, causing them to die and be replaced by healthy cells. The cream is typically applied directly to the affected skin areas once or twice daily, as directed by a healthcare provider. During treatment, the skin may become red, inflamed, and scabbed as the damaged cells are eliminated.
Fluorouracil topical cream should be applied once in a day to the skin where the actinic keratosis lesions appear, using enough in order to cover the affected area with a thin film. Apply the cream 10 minutes after thoroughly washing, rinsing, and drying the entire area.
This cream may be applied using the fingertips up to 4 weeks as tolerated.
Ordinarily, the topical over dosage will not cause acute problems. If fluorouracil cream by mistake ingested, induce emesis and gastric lavage. Symptomatic and supportive care should be administered as required.
The most commonly reported fluorouracil cream side effects include:
redness
dryness
burning
local pain
erosion
swelling
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